m202 Acremonium kiliense

Allergens within Molds and other Microorganisms

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  • Latin name: Acremonium kiliense/Cephalosporium acremonium
  • Family: Moniliacea
  • Source material: Spores and mycelium
Cephalosporium is one of the most common airborne fungi genera.

Allergen Exposure

Cephalosporium acremonium is a soil-inhabiting imperfect fungi and Cephalosporium is one of the most common airborne fungi genera (1). Some species are the source of a group of antibiotics.

Potential Cross-Reactivity

No published data is found.

Clinical Experience

In a study by Martinez Ordaz 1997 (2), the frequency of Cephalosporium sensitivity was 16% in a group of 101 patients with allergic bronchial asthma. Precipitating antibodies to Cephalosporium acremonium have been found in patients with allergic alveolitis (3) and hypersensitivity pnuemonitis (4-6).
 
Review
A soil-inhabiting imperfect fungi of the family Moniliacea, order Moniliales. Some species are the source of a group of antibiotics, a board spectrum penicillinase-resistant drug (including cephalexin, cephaloridine, cephaloglycin, cephalothin). Cephalosporium is one of the most common airborne fungi genera (1).
 
In a study by Martinez Ordaz 1997 (2), the frequency of Cephalosporium sensitivity was 16% in a group of 101 patients with allergic bronchial asthma. Precipitating antibodies to Cephalosporium acremonium have been found in patients with allergic alveolitis (3) and hypersensitivity pnuemonitis (4-6).

References:

    1. Al Doory Y, Domson JF. Mould Allergy. Philadelphia, 1984.
    2. Martinez Ordaz VA, Rincon Castaneda CB, Lopez Campos C, Velasco Rodriguez VM. [Cutaneous hypersensitivity in patients with bronchial asthma in La Comarca Lagunera]. Rev Alerg Mex 1997;44(6):142-5.
    3. Velcovsky HG, Graubner M. [Allergic alveolitis following inhalation of mould spores from pot plant earth (author's transl)]. Dtsch Med Wochenschr 1981;106(4):115-20.
    4. Suda T, Sato A, Ida M, Gemma H, Hayakawa H, Chida K. Hypersensitivity pneumonitis associated with home ultrasonic humidifiers. Chest 1995;107(3):711-7.
    5. Popp W, Braun O, Zwick H, Rauscher H, Ritschka L, Flicker M. Detection of antigen-specific antibodies on lung tissue in a patient with hypersensitivity pneumonitis. Virchows Arch A Pathol Anat Histopathol 1988;413(3):223-6.
    6. Patterson R, Fink JN, Miles WB, et al. Hypersensitivity lung disease presumptively due to Cephalosporium in homes contaminated by sewage flooding or by humidifier water. J Allergy Clin Immunol 1981;68(2):128-32

2000