Birch allergen components

Allergen related documents

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Booklet: Native & Recombinant Allergen Components.
Allergy - Which allergens? Phadia AB, 2006.
 
Recombinant allergen components from pollen of birch are available for allergen-specific IgE antibody testing.
 
Recombinant allergens, which are biotechnology produced protein molecules originally identified from allergen extracts, have immunoglobulin E (IgE) antibody binding comparable to that of natural allergens and generally show excellent reactivity in in vitro and in vivo diagnostic tests (1). To date, many different recombinant allergens of various pollens, molds, mites, bee venom, latex and foods have been cloned, sequenced, and expressed.
 
Recombinant allergens have a wide variety of uses, from the diagnosis and management of allergic patients to the development of immunotherapy to the standardisation of allergenic test products as tools in molecular allergology.
 
Recombinant allergens are particularly useful for further investigations in allergies manifesting wide cross-reactivity, such as allergy to birch pollen, which frequently involves cross-reactivity among pollens of trees belonging to the order Fagales (e.g., Fagaceae, Corylaceae, and Betulaceae) (2). Birch pollen is considered to be the most powerful allergen in this complex (3).
 
 

Allergens from Betula verrucosa listed by
the International Union of Immunological Societies
(IUIS, Feb. 2006)

Bet v 1

Bet v 2

Bet v 3

Bet v 4

Bet v 6

Bet v 7


 

References:

    1. Niederberger V, Stubner P, Spitzauer S, Kraft D, Valenta R, Ehrenberger K, Horak F. Skin test results but not serology reflect immediate type respiratory sensitivity: a study performed with recombinant allergen molecules. J Invest Dermatol 2001 Oct;117(4):848-51.
    2. Valenta R, Breiteneder H, Petternburger K, Breitenbach M, Rumpold H, et al. Homology of the major birch-pollen allergen, Bet v I, with the major pollen allergens of alder, hazel, and hornbeam at the nucleic acid level as determined by cross-hybridization. J Allergy Clin Immunol 1991;87(3):677-82
    3. Mothes N, Valenta R. Biology of tree pollen allergens. Curr Allergy Asthma Rep 2004;4(5):384-90.