| Provoking substance | Possible type of non IgE-mediated reaction | Suggested analysis/analyses |
Acetylsalicylic acid
(=ASA, Aspirin) | Unclear | Challenge test in vivo |
Alcohol, wine:
- aldehyde dehydrogenase
- sulfites
- histamine-liberators | Toxic reaction
Enzymatic defect (intolerance)
Bronchial hyperresponsiveness
Toxic reaction/intolerance | Blood- alcohol concentration
No suggestion
Lung function test (not specific)
Challenge test in vivo/I> |
| Chrome | Type IV hypersensitivity | Patch test in vivo |
| Cold air | Bronchial hyperresponsiveness
Toxic reaction (from histamine) | Lung function test (not specific)
Challenge test in vivo |
| Cosmetics | Type IV hypersensitivity | Patch test in vivo |
| Dextran | Delayed reaction | Specific IgG ab |
| Gliadin | Immune-mediated, non-IgE | ImmunoCAP Gliadin IgA/IgG, reticulin ab/endomysium ab, (tissue transglutaminase ab), jejunal biopsy |
| Heparin | Cytotoxic reaction | Platlet count, skin biopsy |
| Lactose | Enzymatic defect (intolerance | Challenge test in vivo |
| Nickel | Type IV hypersensitivity | Patch test in vivo |
| Paint | Bronchial hyperresponsiveness | Lung function test (not specific) |
| Perfume | Bronchial hyperresponsiveness
Type IV hypersensitivity | Lung function test (not specific)
Patch test in vivo |
| Printing ink | Bronchial hyperresponsiveness | Lung function test (not specific) |
| Sugar | Enzymatic defect (intolerance) | Challenge test in vivo |
| Tobacco smoke | Bronchial hyperresponsiveness | Lung function test (not specific) |
| Washing powder | Bronchial hyperresponsiveness
Skin hyperresponsiveness | Lung function test (not specific)
No suggestion |
| Wool | Skin hyperresponsiveness
Type IV hypersensitivity | No suggestion
Patch test in vivo |