Why is the allergen composition of ImmunoCAP Phadiatop secret?
ImmunoCAP Phadiatop
The exact composition of ImmunoCAP Phadiatop is not essential to know for using the test.
ImmunoCAP Phadiatop (Phadia differentiate atopy) is built around the atopy concept of Dr Pepys, which is the constitutional disposition to produce IgE antibodies to common environmental allergens, whether the patient has clinical symptoms or not (1). Therefore, ImmunoCAP Phadiatop should only be used in patients with allergy or allergy-like symptoms as an initial step aimed at confirming or excluding IgE sensitization, and not to identify the specific allergen. When atopy has been confirmed with ImmunoCAP Phadiatop, the specific allergen follow-up can begin. This follow-up can consist of not only common inhalant allergens, but also other suspected allergens in the environment of the patient.
Reference
- Pepys J. Atopy. In: Gell PGH, Coombes RRA, Lachmann PJ, editors. Clinical Aspects of Immunology. Blackwell Scientific Publications, Oxford. 1975:877-902.