How can the result of ImmunoCAP Phadiatop in a patient be negative despite a positive single IgE test?

ImmunoCAP Phadiatop

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This is not commonly seen, but can happen if the patient is monospecificically allergic to one or a few allergenic components weakly represented on the solid phase of ImmunoCAP Phadiatop. A number of studies showing the excellent performance of ImmunoCAP Phadiatop have been reviewed and commented on by Dr N Eriksson, who found the average sensitivity and specificity to be above 90% (1).
 
Reference
  1. Eriksson N. Allergy screening with Phadiatop and CAP Phadiatop in combination with a questionnaire in adults with asthma and rhinitis. Allergy 1990;45:285-292.  
     
     
     
Further Reading