Sensitivity and Specificity

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A large number of studies have been performed in which the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis has been evaluated.
Clinical performance expressed as sensitivity, ranging from 84-95%, and specificity, ranging from 85-94%, has been reported from multi-center studies including several hundred patients tested for a range of different allergens (1-3).

References:

    1. Johansson SGO, ed. Clinical Workshop. IgE antibodies and the Pharmacia CAP System in allergy. Lidköping: Landströms 1988
       
    2. Pastorello EA, Incorvaia C, Pravettoni V, Bonini S, Canonica GV, Ortoloni C et al. A multicentric study on sensitivity and specificity of a new in vitro test for measurement of IgE antibodies. Ann Allergy 1991;67:365-70
       
    3. Paganelli R et al. Specific IgE antibodies in the diagnosis of atopic disease. Clinical evaluation of a new in vitro test system, UniCAP, in six European allergy clinics. Allergy 1998;53:763-8